The best way is to handle a panel of interviewers is to take them
on one at a time. The board or panel is not one entity, but
several individuals coming together with the common goal of
hiring the best candidate for the job. At the same time, each
person has his own agenda or department's interest at heart. For
example, the HR manager will be checking to make sure you are a
good fit with the culture and people working at this company. The
hiring manager will want to know about your technical skills or
business know-how. And the person from accounting will want to
know if you are savvy enough to operate a business budget.

Board or panel interviews are usually rather formal and
organized, using a standard set of questions for all applicants.
This type of interview is typically used in academia, government
or for high-level executives but can be used for any other type
of position in any company.

Another multiple-type interview is the team or "good cop/bad cop"
interview. The team is usually made up of two interviewers, one
who asks the questions and one who takes notes. The two typically
trade roles, which can be confusing if they have different
styles. In fact, one person may be kind and gentle and the other
more harsh or pushy. Just remember, these inquisitors are working
together toward the same end. Treat them equally, not favoring
one over the other.

Regardless of the type of interview, the best advice is to
prepare and practice beforehand. When you have your script
written and rehearsed your answers, you will feel prepared and
more confident no matter how many people you have to face.

A good tip is to try to shake hands with each member of the panel
before and/or after the interview if at all logistically
possible.

Lastly, remember to make sure you get each person's business
card, hopefully at the beginning of the interview, so you can
address each person by name. And, when you write your
follow-up/thank you note/email you can address each person
correctly. When responding to an individual, try to remember what
he or she was particularly interested in when they asked
questions or received your answer.

Remember each person has an agenda – it is up to you to zero in
on that interest and make the most of it.